Brain-Boosting Supplement Ingredients

The advancing worldwide prevalence of cognitive deterioration and dementia is a global health concern. World Health Organization( WHO) calculates from 2013 suggested that more than 35 million individuals worldwide were living with dementia; the WHO noted it expected that number to almost double every 20 years, reaching 115.4 million by 2050.1

Dietary and nutritional factors impact cognitive status and likely contribute to these staggering numbers. Analyses, for instance, show that dietary protocols such as The Mediterranean Diet may benefit cognitive health. Furthermore, a recent review led by Arrigo Cicero from the University of Bologna( Bologna, Italy) looked at studies published between 1970 and 2017 and concluded that the use of herbs and phytochemicals for delaying the onset of cognitive decline presents significant promise. 2

Nutrition and diet can play a significant role in helping to support cognitive health. Some recent examines analyse the effects of herbs and nutrients on cognition are summarized here.

References:
1. Mavrodaris A et al ., aPrevalences of dementia and cognitive impairment among older people in sub-Saharan Africa: a systematic review, a Bulletin of the World Health Organization, vol. 91 , no. 10( October 1, 2013 ): 773 -7 83

2. Cicero AFG et al ., aBotanicals and phytochemicals active on cognitive decline: the clinical evidence, a Pharmacological Research. Published online Dec 28, 2017.

Vitamin D Enhances Visual Memory
Epidemiological analyses had already been discovered an association between vitamin D and cognitive health. To assess the effect of vitamin D supplementation on cognitive function in a healthy population, Jacqueline Petterson of the University of Northern British Columbia( Canada) conducted an intervention survey. 3

In the randomized trial, 82 healthy adults from British Columbia were asked to supplement with high-dose( 4,000 IU per day) or low-dose( 400 IU per day) vitamin D3 for 18 weeks. All participants had vitamin D levels a $? 100 nmol/ L( a $? 40 ng/ ml) at baseline. Cognitive performance was assessed with the Symbol Digit Modalities Test, verbal fluency, digit span, and the CANTAB computerized battery, a validated digital cognitive function exam developed at the University of Cambridge( United Kingdom ).

According to researchers, serum vitamin D levels increased significantly more in the high-dose vitamin D group than in the low-dose group. Improvements in visual( non-verbal) memory were also noted with high-dose vitamin D supplementation. In those with baseline vitamin D levels <75 nmol/l (<30 ng/ml), the high-dose vitamin d supplement led to highly significant improvement. no such improvement was noted in the low-dose group, indicating that vitamin d supplementation is important for aspects of higher-level cognitive functioning.

References:
3. Pettersen JA., aDoes high dose vitamin D supplementation enhance cognition?: A randomized trial in healthy adults,a Experimental Gerontology, vol. 90 (April 2017): 90-97

Spearmint Bolsters Working Memory
A proprietary extract of spearmint that is high in polyphenols, including rosmarinic acid, was recently analyse for its effects on cognitive health. In a study led by Kelly Herrlinger from ingredients firm Kemin( Des Moines, IA ), researchers aimed to evaluate the benefits of the extract, branded Neumentix, in adults with age-associated memory impairment. 4

In the double-blind, placebo-controlled analyze, 90 adults with an average age of 59.4 years were divided into three groups: one group received a placebo while the other two received either 600 mg or 900 mg per day of the Neumentix spearmint extract for 90 days. Cognitive evaluations included the validated Cognitive Drug Research( CDR) system, while additional evaluations included the Leeds Sleep Evaluation Questionnaire( LSEQ) and the Profile of Mood State( POMS) ratings scale.

After 90 days, significant benefits were seen in different groups taking 900 mg of spearmint extract daily, including improved quality of working memory and spatial running memory. Additionally, 900 mg/ day of the spearmint extract led to significant improvement versus placebo in the LSEQ, specifically as related to the aease of getting to sleepa parameter. These outcomes suggest that the Neumentix polyphenol-rich spearmint extract may be beneficial for those working with age-associated memory impairment.

References:
4. Herrlinger KA et al ., aSpearmint extract improves working memory in men and women with age-associated memory impairment, a The Journal of Alternative and Complementary Medicine, vol. 24 , no. 1( January 2018 ): 37 -4 7

Omega-3s for Mild Cognitive Impairment
The importance of omega-3 fatty acidsaand especially docosahexaenoic acid( DHA) afor brain development is widely known. Several epidemiological studies support the benefits of higher omega-3 uptakes for brain-health maintenance. However, the clinical effects of omega-3 supplementation are less clear.

Researchers from Zhengzhou University( Zhengzhou, China) lately conducted a randomized, double-blind, placebo-controlled study in 86 adults with mild cognitive impairment in which individuals received supplements containing 480 mg DHA and 720 mg EPA daily, or a placebo, for 6 months. 5 Changes to cognitive function were assessed using the Basic Cognitive Aptitude Test( BCAT ).

Based on the parameters assessed, omega-3 supplementation led to statistically significant improvements in total BCAT ratings, perceptual velocity, working memory, and spatial imagery efficiency, but not in mental arithmetic efficiency or recollect. The outcomes indicate that omega-3 fatty acid supplementation may be beneficial in supporting cognitive function in people with mild cognitive impairment.

References:
5. Bo Y et al ., aThe n-3 polyunsaturated fatty acids supplementation improved the cognitive function in the Chinese elderly with mild cognitive impairment: a double-blind randomized controlled trial, a Nutrients, vol. 9 , no. 1( January 10, 2017)

Lutein and Zeaxanthin
The macular carotenoids lutein and zeaxanthin are well-known for their eye- and macular-health benefits. However, recent analyses have shown that these carotenoids are important for more than just the eyes. Two trials led by Lisa Renzi-Hammond and Billy Hammond from the University of Georgia( Athens, GA) suggest that lutein and zeaxanthin supplementation can support several aspects of cognitive function in both young and matured adults. The analyzes were conducted on Lutemax 2020, food ingredients from OmniActive Health Technologies( Morristown, NJ ).

In one randomized, double-blind, placebo-controlled trial, researchers included 51 healthy young adults aged 18 -3 0.6 Participants were asked to supplement with 10 mg of lutein plus 2 mg of zeaxanthin daily, or a placebo, for one year. Macular pigment optical density( MPOD) and cognitive function using the CNS Vital Signs computerized test battery were assessed every four months. MPOD levels significantly improved over the course of the year compared to placebo, and the team find corresponding significant improvements in spatial memory, reasoning ability, and complex attention, indicating the added benefit of supplementation for cognitive function in a young population.

In a second, double-blind, placebo-controlled trial, 62 adults with an average age of 73 were randomized to supplement with 10 mg of lutein and 2 mg of zeaxanthin daily, or a placebo, for a year. 7 Researcher noted significant improvements in MPOD, and the CNS Vital Signs assessment depicted significant improvements in complex attention as well as cognitive flexible. In the male participants, significant improvements were additionally seen in composite memory, is recommended that supplementation with lutein and zeaxanthin is beneficial for enhancing aspects of cognition in this population as well.

References:
6. Renzi-Hammond LM et al ., aEffects of a lutein and zeaxanthin intervention on cognitive function: a randomized, double-masked, placebo-controlled trial of younger healthy adults, a Nutrients, vol. 9 , no. 11( November 14, 2017)

Source: Nutritional Outlook

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