Piperine, Curcumin Complex Reduces Total Body Fat in Animal Study

ORIGINAL ARTICLE: A http :// www.nutritionaloutlook.com/ herbs-botanicals/ piperine-curcumin-complex-reduces-total-body-fat-animal-study

A new, independent study1 be carried out in scientists at Jane Mayer U.S. Department of Agriculture Human Nutrition Center for Aging at Tufts University( Boston) and Tohoku University( Miyagi, Japan) found that Sabinsaas( East Windsor, NJ) BioPerine black pepper extract and Curcumin C3 complex work together to help modulate body fat accumulation in obese mouse. Sabinsa says that the results from this animal analyze add to the companyas existing research highlighting the synergistic effects of piperine combined with curcumin.

Existing research suggests that specific dietary components found in spices may have a beneficial effect on metabolism, such studies writers add. For the purposes of this study, the researchers focused on curcumin, the major polyphenol in turmeric( Curcuma longa ), and piperine, the bioactive alkaloid in pepper. Curcumin is said to possess anti-inflammatory and anti-obesity properties, while piperine has been shown to increase curcuminas absorption and bioavailability in the body. In addition, the two ingredients together may also help to attenuate inflammation.

In the study, the researchers mimicked the kind of caloric limited regimen an obese individual might undertake to lose weight, including potentially accelerating the loss of body weight by blending the regimen with dietary bioactive compounds or narcotics known to increase metabolism and weight loss.

During the first phase of the study, researchers fed 47 mice a high-fat diet for 23 weeks to induce obesity. The mouse was later divided into five groups. While one group continues to ingest the high-fat diet ad libitum, the other four cohorts underwent a caloric-restriction program including a 10% reduction in food intake for 10 weeks, followed by a 20% reduction in food intake for 20 weeks. In addition, the mouse were supplemented with either 1) 1 g/ kg curcumin; 2) 50 mg/ kg piperine; 3) 1 g/ kg curcumin plus 50 mg/ kg piperine; or 4) none of the above.

Researchers measured the miceas body weight twice per week. Starting from week 23, the researchers measured the miceas body weight once every two weeks use an animal magnetic resonance imaging( MRI) system( EcoMRI ). They also recorded the miceas body fat percentages, as well as the plasma inflammatory markers associated with obesity. The researchers also measured plasma curcumin metabolites and length of the liver telomeres, or the protective end-caps on the end of chromosomes. In addition to modulating energy expenditure and body fat metabolism, caloric limited helps to regulate telomere length. Telomeres help to preserve the integrity of DNA. The survey writers write that one of the factors indicative of cellular health is the length of the telomeres. Shortened telomeres indicate cellular senescence and aging.

At the end of the 53 -week study period, all mouse fed the high-fat diet had gained substantial amounts of body weight, with up 49% of their total weight consisting of body fat. When the researchers curtailed the caloric intake of the mouse by 10%, weight gain stabilized, while percentages per of total body fat increased. When the researchers increased the caloric restriction by 20%, the mice did lose body weight, though percentages per of body fat remained significant. Neither curcumin, piperine, or the curcumin-piperine combination affected the rate of weight loss; however, the miceas body fat percentage was reduced through supplementation with the curcumin-piperine combination.

The mice supplemented with the combination of curcumin and piperine also exhibited considerably reduced amounts of adiposity compared with the ad libitum group, but the groups that received curcumin or piperine alone did not demonstrate increased body fat loss. In addition, the mouse given the combination of curcumin and piperine did find a decrease in some of the inflammatory cytokine markers associated with obesity, but curcumin and piperine had no effect on other inflammatory markers.

Finally, the researchers measured the telomere length in the livers of the obese mice. The caloric-restriction program alone was not effective in increasing the length of the telomeres, but the abbreviate of the telomeres was attenuated in the cohort supplemented with the curcumin-piperine combination. The researchers concluded that awhen[ a high-fat diet] regimen is subjected to[ caloric restriction] immediately, telomere duration is probably affected by oxidative stress. However, the inclusion of[ curcumin] or[ piperine] into the diet repressed telomere abbreviating to some extent. This effect was further enhanced when[ curcumin plus piperine] was included in the diet.a

Nagabhushanam Kalyanam, PhD, president, the investigations and developing, Sabinsa, elaborated on the study results in a press statement: aOn the whole, it was concluded that this nutrient combination, curcumin-piperine, works well to reduce total body fat, reduces cellular aging as indicated by preserving telomere duration, and enhance the[ caloric regulation] consequences for the prevention of metabolic syndrome by reducing the low grade chronic inflammation that always persists in obese conditions.a

Miyazawa T et al ., aCurcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1I 2, a Nutrition and Metabolism. Published online February 6, 2018.

Source: Nutritional Outlook

ORIGINAL ARTICLE: http :// www.nutritionaloutlook.com/ herbs-botanicals/ piperine-curcumin-complex-reduces-total-body-fat-animal-study

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