The secret to longevity is in the microbiome and the gut
Experiments in fruit flies show increased lifespan thanks to a combination of probiotics and an herbal supplement
McGill University 😛 TAGEND
This research was funded by the Natural Science and Engineering Research Council of Canada and the Canadian Institute of Health Research.
aLongevity extension in Drosophila through gut-brain communication, a by Susan Westfall, Nikita Lomis and Satya Prakash ., Scientific Reports
You are what you eat. Or so the saying goes. Science now tells us that we are what the bacteria living in our intestinal tract eat and this could have an influence on how well we age. Build on this, McGill University scientists fed fruit flies with a combination of probiotics and an herbal supplement called Triphala that was able to prolong the flies’ longevity by 60 % and protect them against chronic illness associated with aging.
The study, published in Scientific Reports, adds to a growing body of evidence of the influence that gut bacteria can have on health. The researchers incorporated a symbiotic- made of probiotics with a polyphenol-rich supplement- into the diet of fruit flies.
The flies fed with the synbiotic lived up to 66 days old- 26 days more than the ones without the supplement. They also depicted reduced traits of aging, such as mounting insulin resistance, inflammation and oxidative stress.
” Probiotics dramatically change the architecture of the intestine microbiota , not only in its composition but also in respect to how the foods that we eat are metabolized ,” says Satya Prakash, prof of biomedical engineering in McGill’s Faculty of Medicine and senior writer of the study.” This allows a single probiotic formulation to simultaneously act on several biochemical signaling pathways to elicit broad beneficial physiological consequences, and explains why the single formulation we present in this paper has such a dramatic consequence on so many different markers “.
The fruit fly is remarkably similar to mammals with about 70 % similarity in terms of their biochemical pathways, stimulating it a good indicator of what would happen in humen, adds Prakash.
” The impacts in humans is very likely to not be as dramatic, but our results definitely suggest that a diet specifically incorporating Triphala along with these probiotics will promote a long and healthy life .”
The writers also say that the findings can be explained by the” gut-brain axis ,” a bidirectional communication system between microbes residing in the gastrointestinal tract- the microbiota- and the brain. In the past few years, examines have shown the gut-brain axis to be involved in neuropathological changes and a variety of conditions such as irritable bowel disorder, neurodegeneration and even depression. Few analyses, however, have successfully designed gut microbiota-modulating therapeutics having consequences as potent or broad as the formulation presented in the new study.
Learning from traditional medicine
The herbal supplement used in the study, Triphala, is a formulation made from amalaki, bibhitaki and haritaki, fruit used as medicinal plants in Ayurveda, a form of traditional Indian medicine.
Susan Westfall, a former PhD student at McGill and lead writer of the study, tells the idea of combining Triphala and probiotics comes from her long-standing interest in examining natural products derived from traditional Indian medication and their impact on neurodegenerative diseases.
” At the onset of this study, we were hopeful that blending Triphala with probiotics would be at least a little better than their individual components in terms of physiological benefit, but we did not imagine how successful this formulation would be ,” says Westfall, who is now a postdoctoral fellow at the Icahn School of Medicine at Mount Sinai in New York, USA.
The new study, which includes data filed in a US provisional patent through a company cofounded by the authors, may then impact the field of the microbiome, probiotics and human health.
Considering the broad physiological effects of this formulation shown in the fruit fly, Prakash hopes their formulation could have interesting applications in a number of human disorders such as diabetes, obesity, neurodegeneration, chronic inflammation, depression, irritable bowel syndrome and even cancer.
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