Saffron Extract Improves Depression and Anxiety in Teenagers, in New Study

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Results from a new study1 published in the Journal of Affective Disorders indicates that saffron( Crocus sativus L .) may help reduce depression and anxiety symptoms in teenage infants. The first-of-its-kind examine found that supplementation with Affron, a branded saffron extract ingredient from biotechnology firm Pharmactive Biotech Products ( Madrid ), improved impressions of separation nervousnes, social phobia, and depression in young people.

The randomized, double-blind, placebo-controlled examine included 68 young people between the ages of 12-16 with mild-to-moderate anxiety or depressive symptoms. According to data from the World Health Organization, the study writers write, psychiatric disorders including nervousnes and depression are among the leading causes of disability in young people, with as much as 15% -2 0% of the youth population experiencing an anxiety or depressive disorder before persons under the age of 18. Saffron, they add, has been shown to be effective in reducing feelings of depression and nervousnes in adults with mild-to-moderate depression. However, saffron for depression and anxiety had not yet been studied in a youth population prior to publication of the current analyse, they said.

The researchers divided participants into two groups. One group received 14 mg Affron, while another group received the same dosage of a placebo. Both group were instructed to take one tablet of either Affron or the placebo twice daily for a total of eight weeks. In order to determine what effects supplementation with Affron had on parameters of anxiety and depression, participants completed a 47 -item questionnaire called the Rewritten Child Anxiety and Depression Scale( RCADS ). RCADS includes subscales on separation nervousnes, social phobia, general anxiety, anxiety, preoccupations and compulsions, and depression. Subjectsa parents also completed the parent-report version of RCADS; those results served as the secondary outcome measure.

The group supplemented with Affron reported improvements in overall internalizing symptoms, separation nervousnes, social phobia, and depression, compared with the placebo group. Parental reports of improvement in the subjectsa mental health were inconsistent. The researchers thus concluded that aadministration of a standardized saffron extract( Affron) for eight weeks improved nervousnes and depressive symptoms in youth with mild-to-moderate symptoms, at least from the perspective of the adolescent.a Affron was also found to be safe and well-tolerated.

The study writers write that while the results are encouraging, the self-reporting nature of this study represents a limitation. The limited analyse duration, single therapy dose, and non-clinical sample used in this study similarly limit the overall generalizability of research results, warranting the need for further investigation. Pharmactive Biotech Products funded the study.

1. Lopresti AL et al ., aAffron, a standardized extract from saffron( Crocus sativus L .) for treatment of youth nervousnes and depressive symptoms: a randomized, double-blind, placebo-controlled analyse, a Journal of Affective Disorders. Published online February 26, 2018.

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